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 V. Knott, T. Gunnarsson, C. Mahoney,
J. Shlik, J. Bradwejn
University of Ottawa, Canada
University Hospital, Linkoping, Sweden
University of Tartu, Estonia


Effects of Acute Cholecystokinin Tetrapeptide Administration on Brain Stem Auditory Evoked Potentials in Healthy Volunteers

V. Knott, T. Gunnarsson, C. Mahoney, J. Shlik, J. Bradwejn


Abstract

This study investigated the effects of continuous slow intravenous infusion of cholecystokinin tetrapeptide (CCK-4) on brain stem auditory evoked potentials (BSAEP) in healthy subjects. These preliminary findings suggest that CCK-4 may interfere with information processing in the brain stem auditory pathways and that prolonged intravenous CCK-4 administration may be a useful challenge paradigm for investigating CCK's modulatory role on brain stem mechanisms mediating anxiety and panic in humans.